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Contestants, regardless of their weight, are required to certify that they believe they are "in excellent physical, emotional, psychological and mental health".
The Biggest Loser: Second Chances included a one-mile foot race in its first week, an event that led to the hospitalization of two of its contestants; Rob Huizenga, the show's medical consultant, when asked about the foot race said that "If we had it to do over, we wouldn't [have done] it" and noted that in response, the show's producers have "changed a lot of the way [they] do things" (including the close monitoring of contestants' body temperatures during exercise).
Featured 12 contestants divided into two teams, the Red team and the Blue team.
The Red Team was coached by trainer Jillian Michaels, while The Blue Team was coached by trainer Bob Harper.
The contestants are grouped into teams of two, each wearing separate colored t-shirts.
When the number of contestants has shrunk to a predetermined smaller number (unknown to the contestants), the teams are dissolved and the contestants compete one-on-one against each other.
The season finale features both the contestants remaining on the show and those sent home early; the latter are brought back for the final show.
Season two introduced the change that weigh-ins would be won or lost based on the percentage of total weight lost, rather than on the number of pounds lost.
This change was made to create a more even playing field among contestants of varying weights. Contestants Suzy Preston and Matt Hoover (third place finisher and winner, respectively) began dating after the show and later married (revealed in an interview on Larry King Live).